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KMID : 0376219840210020363
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Chonnam Medical Journal
1984 Volume.21 No. 2 p.363 ~ p.367
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The Effet of Pretreated Diazepam on the Succinylcholine induced Fasciculation
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Abstract
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Succinylcholine, one of non-depolarizing neuromuscular blocking agents, is rapid in its action and excellent in neuromuscular blocking effect. Therefore it is widely used in general endotracheal anesthesia for facilitating the endotracheal intubation.
However, adverse effects such as fasciculation and increase in serum K+ level following intravenous succinylcholine administration may develop. Accordingly, in order to decrease or prevent these adverse effects, we used the intravenous diazepam which attenuates the muscle tone before intravenous succinycholine administration.
Alterations in succinylcholine induced fasciculation, changes in serum K+ level, and degree of vocal cord paralysis were evaluated.
The results were as follows.
1) The incidence of severe fasciculation is about 40% in control group and 13% in study group. In both groups, changes in the serum potassium level are statistically Ron-significant.
2) In both groups remarkable vocal cord paralyses were well documented.
3) From the above results, it can be assumed that although pretreated diazepam can decrease the degree of fascicualtion caused by succinylcholine, there may be no effect on neuromuscular blocking action induced by succinylcholine.
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